Microbiological test for leucine, valine, and isoleucine using urine sample dried on filter paper.

نویسندگان

  • H K BERRY
  • C SCHEEL
  • J MARKS
چکیده

Urine specimens dried on filter paper squares were obtained from 700 mentally retarded children. A microbiological assay was used to screen the specimens for the presence of valine, leucine, and isoleucine. Three specimens gave positive tests for all three amino acids. A generalized aminoaciduria was observed in two specimens, and in the third, elevation of valine and leucine/isoleucine was confirmed by paper chromatography. The use of these screening procedures for early detection of children with maple sugar urine disease is suggested.

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عنوان ژورنال:
  • Clinical chemistry

دوره 8  شماره 

صفحات  -

تاریخ انتشار 1962